Efecto de los probióticos en el rendimiento productivo y de salud en bovinos: Una revisión/Effect of probiotics on cattle health and performance: A review
Resumen
Los probióticos han emergido como una alternativa prometedora en la producción ganadera bovina, especialmente frente al uso prolongado de antibióticos, el cual ha generado resistencia bacteriana, residuos en productos de origen animal y riesgos para la salud pública. La investigación, realizada entre abril y mayo de 2025, incluye una revisión de la literatura científica publicada entre los años 2000 y 2025, disponible en bases de datos como Semantic Scholar, Scopus y Google Scholar; que se complementa con herramientas digitales como Elicit y Research Rabbit. Los resultados destacan beneficios significativos como la reducción en la incidencia y severidad de diarreas en terneros, acompañada de un crecimiento más estable; mientras que, en vacas lecheras se registraron mejoras en la composición de la carne y la leche e incrementos en la producción de esta última, así como una mayor ganancia de peso y eficiencia alimenticia. Estos hallazgos posicionan a los probióticos como una herramienta estratégica para avanzar hacia sistemas ganaderos más sostenibles; no obstante, persisten desafíos ante la brecha de conocimientos existente en varios estudios, como la falta de especificación de cepas y de dosis utilizadas, lo que dificulta la comparación de resultados y limita la formulación de recomendaciones prácticas para su aplicación en campo; por lo que este estudio propone analizar la evidencia científica disponible sobre los efectos del uso de probióticos en bovinos, considerando su impacto en la salud y el rendimiento productivo.
Palabras clave: animal; bienestar; bobinos; inmunidad; probióticos
ABSTRACT
Probiotics have emerged as a promising alternative in bovine livestock production, particularly in the face of prolonged antibiotic use, which has led to bacterial resistance, residues in animal products, and risks to public health. The research, conducted between April and May 2025, includes a review of the scientific literature published between 2000 and 2025, available in databases such as Semantic Scholar, Scopus, and Google Scholar, supplemented with digital tools such as Elicit and Research Rabbit. The results highlight significant benefits such as a reduction in the incidence and severity of diarrhea in calves, accompanied by more stable growth. In dairy cows, improvements in meat and milk composition, increases in milk production, as well as greater weight gain and feed efficiency were recorded. These findings position probiotics as a strategic tool for advancing toward more sustainable livestock systems. However, challenges persist due to knowledge gaps identified in several studies, such as the lack of specification of strains and doses used, which hinders the comparison of results and limits the formulation of practical recommendations for field application. Therefore, this study aims to analyze the available scientific evidence on the effects of probiotic use in cattle, considering its impact on health and productive performance.
Keywords: animal; welfare; cattle; immunity; probiotics
Descargas
Citas
Ahmed, S. T., Hoon, J., Mun, H.-S. & Yang, Ch.-J. (2014). Evaluation of Lactobacillus and Bacillus-based probiotics as alternatives to antibiotics in enteric microbial challenged weaned piglets. African Journal of Microbiology Research, 8(1), 96-104. https://doi.org/10.5897/AJMR2013.6355
Alawneh, J. I., Barreto, M. O., Moore, R. J., Soust, M., Al-Harbi, H., James, A. S., Krishnan, D. & Olchowy, T. W. J. (2020). Systematic review of an intervention: the use of probiotics to improve health and productivity of calves. Preventive Veterinary Medicine, 183, e105147. https://doi.org/10.1016/j.prevetmed.2020.105147
Al-Shawi, S. G., Dang, D. S., Yousif, A. Y., Al-Younis, Z. K., Najm, T. A. & Matarneh, S. K. (2020). The Potential Use of Probiotics to Improve Animal Health, Efficiency, and Meat Quality: A Review. Agriculture, 10(10), e452. https://doi.org/10.3390/agriculture10100452
Anee, I. J., Alam, Sh., Begum, R. A., Shahjahan, R. M. & Khandaker, A. M. (2021). The role of probiotics on animal health and nutrition. The Journal of Basic and Applied Zoology, 82(52), 1-16. https://link.springer.com/content/pdf/10.1186/s41936-021-00250-x.pdf
Arenas, S. E., Reis, L. S., Frazatti-Gallina, N. M., Giuffrida, R. & Pardo, P. E. (2007). Efeito do probiótico proenzime no ganho de peso em bovinos. Archivos de Zootecnia, 56(213), 75–78. https://www.redalyc.org/pdf/495/49556011.pdf
Arias Aleman, L., Ulloa Ramones, L., Rojas Oviedo, L. y Condo Plaza, L. (2019). Efecto de la suplementación alimenticia y el Axonopus scoparius en terneros Charolais en el cantón Morona. Ciencia Digital, 3(3.2), 113–121. https://doi.org/10.33262/cienciadigital.v3i3.2.719
Arsène, M. M. J., Davares, A. K. L., Andreevna, S. L., Vladimirovich, E. A., Carime, B. Z., Marouf, R. & Khelifi, I. (2021). The use of probiotics in animal feeding for safe production and as potential alternatives to antibiotics. VeterinaryWorld, 14(2), 319–328. https://doi.org/10.14202/vetworld.2021.319-328
Bacardi-Sarmiento, E. F. (2021). Efectos de los probióticos, prebióticos y simbióticos sobre la microbiota intestinal. EsTuSalud, 3(3), e67. https://revestusalud.sld.cu/index.php/estusalud/article/view/67
Badhan, A., Wang, Y., Terry, S., Gruninger, R., Guan, L. L. & McAllister, T. A. (2025). Invited review: Interplay of rumen microbiome and the cattle host in modulating feed efficiency and methane emissions. Journal of Dairy Science, 108(6), 5489–5501. https://europepmc.org/article/med/40221043
Batista, L. H. C., Cidrini, I. A., Prados, L. F., Cruz, A. A. C., Torrecilhas, J. A., Siqueira, G. R. & Resende, F. D. (2022). A meta-analysis of yeast products for beef cattle under stress conditions: Performance, health and physiological parameters. Animal Feed Science and Technology. https://doi.org/10.1016/j.anifeedsci.2021.115182
Bergamaschi, M., Tiezzi, F., Howard, J., Huang, Y. J., Gray, K. A., Schillebeeckx, C., McNulty, N. P. & Maltecca, Ch. (2020). Gut microbiome composition differences among breeds impact feed efficiency in swine. Microbiome, 8, e110. https://doi.org/10.1186/s40168-020-00888-9
Brodzki, P., Gorzkoś, H., Marczuk, J., Lisiecka, U., Junkuszew, A., Krakowski, L., Szczubiał, M., Brodzki, N. & Głodkowska, K. (2024). The influence of probiotic administration on the phagocytic and oxidative burst activity of neutrophils and monocytes in the peripheral blood of dairy cows during different lactation periods. Journal of Veterinary Research, 68(3), 401–408. https://doi.org/10.2478/jvetres-2024-0043
Cai, X., Yi, P., Chen, X., Wu, J., Lan, G., Li, S. Luo, S., Huang, F., Huang, J. & Shen, P. (2024). Intake of compound probiotics accelerates the construction of immune function and gut microbiome in Holstein calves. Microbiology Spectrum, 12(6), e01909-23. https://doi.org/10.1128/spectrum.01909-23
Cangiano, L. R., Yohe, T. T., Steele, M. A. & Renaud, D. L. (2020). Invited Review: Strategic use of microbial-based probiotics and prebiotics in dairy calf rearing. Applied Animal Science, 36(5), 630–651. https://www-sciencedirect-com.translate.goog/science/article/pii/S259028652030135X?_x_tr_sl=en&_x_tr_tl=es&_x_tr_hl=es&_x_tr_pto=tc
Carattoli, A. (2013). Plasmids and the spread of resistance. International Journal of Medical Microbiology, 303(6-7), 298–304. https://doi.org/10.1016/j.ijmm.2013.02.001
Cholewińska, P., Górniak, W. & Wojnarowski, K. (2021). Impact of selected environmental factors on microbiome of the digestive tract of ruminants. BMC Veterinary Research, 17, e25. https://doi.org/10.1186/s12917-021-02742-y
Cuenca, M., Chauca, J., García, C. & Sigüencia, H. (2022). Saccharomyces cerevisiae as a replacement alternative to growth-promoting antibiotics in animal feed. Archivos de Zootecnia, 71(273), 62–69. https://doi.org/10.21071/az.v71i273.5612
Daghio, M., Ciucci, F., Buccioni, A., Cappucci, A., Casarosa, L., Serra, A., Conte, G., Viti, C., McAmmond, B. M., Van Hamme, J. D. & Mele, M. (2021). Correlation of Breed, Growth Performance, and Rumen Microbiota in Two Rustic Cattle Breeds Reared Under Different Conditions. Frontiers in Microbiology, 12, e652031. https://doi.org/10.3389/fmicb.2021.652031
Deng, Q., Odhiambo, J. F., Farooq, U., Lam, T., Dunn, S. M. & Ametaj, B. N. (2016). Intravaginal probiotics modulated metabolic status and improved milk production and composition of transition dairy cows. Journal of Animal Science, 94(2), 760–770. https://doi.org/10.2527/jas.2015-9650
Du, S., Bu, Z., You, S., Jiang, Z., Su, W., Wang, T. & Jia, Y. (2023). Integrated rumen microbiome and serum metabolome analysis responses to feed type that contribution to meat quality in lambs. Animal microbiome, 5, e65. https://doi.org/10.1186/s42523-023-00288-y
Duarte, M. E. & Kim, S. W. (2022). Intestinal microbiota and its interaction to intestinal health in nursery pigs. Animal Nutrition, 8(1), 169–184. https://doi.org/10.1016/j.aninu.2021.05.001
El Jeni, R., Villot, C., Koyun, O. Y., Osorio-Doblado, A., Baloyi, J. J., Lourenco, J. M., Steele, M. & Callaway, T. R. (2024). Invited review: “Probiotic” approaches to improving dairy production: Reassessing “magic foo-foo dust”. Journal of Dairy Science, 107(4), 1832-1856. https://doi.org/10.3168/jds.2023-23831
Fan, P., Kim, M., Liu, G., Zhai, Y., Liu, T., Driver, J. D. & Jeon, K. C. (2021). The gut microbiota of newborn calves and influence of potential probiotics on reducing diarrheic disease by inhibition of pathogen colonization. Frontiers in Microbiology, 12, 772863. https://doi.org/10.3389/fmicb.2021.772863
Gharechahi, J., Vahidi, M. F., Sharifi, G., Ariaeenejad, S., Ding, X.-Z., Han, J.-L. & Salekdeh, G. H. (2023). Lignocellulose degradation by rumen bacterial communities: New insights from metagenome analyses. Environmental Research, 229, 115925. https://doi.org/10.1016/j.envres.2023.115925
Gutiérrez Castro, L. y Güechá Castillo, A. Y. (2016). Uso de probióticos en alimentación animal. Revista Sistemas de Producción Agroecológicos, 7(2), 43–55. https://doi.org/10.22579/22484817.687
He, Z. X., Ferlisi, B., Eckert, E., Brown, H. E., Aguilar, A. & Steele, M. A. (2017). Supplementing a yeast probiotic to pre-weaning Holstein calves: Feed intake, growth, and fecal biomarkers of gut health. Animal Feed Science and Technology, 226, 81–87. https://doi.org/10.1016/j.anifeedsci.2017.02.010
Iñiguez Heredia, F. A., Espinoza Bustamante, X. E. & Galarza Molina, E. L. (2021). Uso de probióticos y ácidos orgánicos como estimulantes del desarrollo de aves de engorde: artículo de revisión. ALFA Revista de Investigación en Ciencias Agronómicas y Veterinarias, 5(14), 166–172. https://doi.org/10.33996/revistaalfa.v5i14.107
Jiang, X., Xu, H. J., Cui, Z. Q. & Zhang, Y. G. (2020). Effects of supplementation with Lactobacillus plantarum 299v on the performance, blood metabolites, rumen fermentation and bacterial communities of preweaning calves. Livestock Science, 239, 104120. https://doi.org/10.1016/j.livsci.2020.104120
Kayasaki, F., Okagawa, T., Konnai, S., Kohara, J., Sajiki, Y., Watari, K., Ganbaatar, O., Goto, S., Nakamura, H., Shimakura, H., Minato, E., Kobayashi, A., Kubota, M., Terasaki, N., Takeda, A., Noda, H., Honma, M., Maekawa, N., Murata, S. & Ohashi, K. (2021). Direct evidence of the preventive effect of milk replacer–based probiotic feeding in calves against severe diarrhea. Veterinary Microbiology, 254, 108976. https://doi.org/10.1016/j.vetmic.2020.108976
Klopp, R. N., Yoon, I., Eicher, S. & Boerman, J. P. (2022). Effects of feeding Saccharomyces cerevisiae fermentation products on the health of Holstein dairy calves following a lipopolysaccharide challenge. Journal of Dairy Science, 105(2), 1469–1479. https://doi.org/10.3168/jds.2021-20341
Lei, X. J., Zhu, Y., Zhang, X., Yao, J. & Cao, Y. (2025). Animal feed and gut microbiome engineering toward the maintenance of animal health. In D. Dhanasekaran, A. Sankaranarayanan & P. Sarkar (Eds.), Human and Animal Microbiome Engineering (pp. 305–329). Churchill Livingstone. https://doi.org/10.1016/B978-0-443-22348-8.00018-0
Li, Y., Mao, K., Zang, Y., Lu, G., Qiu, Q., Ouyang, K., Zhao, X., Song, X., Xu, L., Liang, H. & Qu, M. (2023). Revealing the developmental characterization of rumen microbiome and its host in newly received cattle during receiving period contributes to formulating precise nutritional strategies. Microbiome, 11, 238. https://doi.org/10.1186/s40168-023-01682-z
Liu, B., Wang, Ch., Huasai, S., Han, A., Zhang, J., He, L. & Aorigele, Ch. (2022). Compound probiotics improve the diarrhea rate and intestinal microbiota of newborn calves. Animals, 12(3), 322. https://doi.org/10.3390/ani12030322
Mansilla, F. I., Ficoseco, C. A., Miranda, M. H., Puglisi, E., Nader-Macías, M. E. F., Vignolo, G. M. & Fontana, C. A. (2022). Administration of probiotic lactic acid bacteria to modulate fecal microbiome in feedlot cattle. Scientific Reports, 12, 12957. https://doi.org/10.1038/s41598-022-16786-z
Mumme, C. A. & Abrahim, M. (2024). Review on probiotic and health benefit in dairy cattle. EAS Journal of Veterinary Medical Science, 6(2), 32–43. https://doi.org/10.36349/easjvms.2024.v06i02.002
Nalla, K., Manda, N. K., Dhillon, H. S., Kanade, S. R., Rokana, N., Hess, M. & Puniya, A. K. (2022). Impact of Probiotics on Dairy Production Efficiency. Frontiers in Microbiology, 13, 805963. https://doi.org/10.3389/fmicb.2022.805963
Olchowy, T. W. J., Soust, M. & Alawneh, J. (2019). The effect of a commercial probiotic product on the milk quality of dairy cows. Journal of Dairy Science, 102(3), 2188-2195. https://doi.org/10.3168/jds.2018-15411
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., … Moher, D. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, 372(71), 1-9. https://doi.org/10.1136/bmj.n71
Peng, M., Patel, P., Nagarajan, V., Bernhardt, C., Carrion, M. & Biswas, D. (2019). Feasible options to control colonization of enteric pathogens with designed synbiotics. In Foods, nutrients and dietary supplements (pp. 135–149). Academic Press. https://doi.org/10.1016/B978-0-12-814468-8.00011-9
Punetha, M., Roy, A. K., Ajithakumar, H. M., Para, I. A., Gupta, D., Singh, M. & Bharati, J. (2018). Immunomodulatory effects of probiotics and prilled fat supplementation on immune genes expression and lymphocyte proliferation of transition stage Karan Fries cows. Veterinary World, 11(2), 209–214. https://doi.org/10.14202/vetworld.2018.209-214
Ravanal, M. C., Contador, C. A., Wong, W.-T., Zhang, Q., Roman-Benn, A., Ah-Hen, K. S., Ulloa, P. E. & Lam, H.-M. (2025). Prebiotics in animal nutrition: Harnessing agro-industrial waste for improved gut health and performance. Animal Nutrition, 21, 179–192. https://doi.org/10.1016/j.aninu.2024.11.025
Rodríguez-González, S., González-Dávalos, L., Shimada Miyasaka, A. & Mora-Izaguirre, O. (2023). Potencial probiótico de bacterias obtenidas de la microbiota de becerros. Archivos Latinoamericanos de Producción Animal, 31(3), 231–242. https://dialnet.unirioja.es/servlet/articulo?codigo=9169641
Stefańska, B., Sroka, J., Katzer, F., Goliński, P. & Nowak, W. (2021). The effect of probiotics, phytobiotics and their combination as feed additives in the diet of dairy calves on performance, rumen fermentation and blood metabolites during the preweaning period. Animal Feed Science and Technology, 272, 114738. https://doi.org/10.1016/j.anifeedsci.2020.114738
Suárez, C. & Guevara, C. A. (2018). Probiotic use of yeast Saccharomyces cerevisiae in animal feed. Research Journal of Zoology, 1(1), 1–6. https://www.scitechnol.com/peer-review/probiotic-use-of-yeast-saccharomyces-cerevisiae-in-animal-feed-BbCv.php?article_id=7094
Sun, X., Wang, Y., Wang, E., Zhang, S., Wang, Q., Zhang, Y., Wang, Y., Cao, Z., Yang, H., Wang, W. & Li, S. (2021). Effects of Saccharomyces cerevisiae Culture on Ruminal Fermentation, Blood Metabolism, and Performance of High-Yield Dairy Cows. Animals, 11(8), 2401. https://doi.org/10.3390/ani11082401
Tesfaye, A. & Hailu, Y. (2019). The effects of probiotics supplementation on milk yield and composition of lactating dairy cows. The Journal of Phytopharmacology, 8(1), 12–17. https://phytopharmajournal.com/assets/pdf_files/Vol8_Issue1_04.pdf
Trabelsi, I., Ben Slima, S., Ktari, N., Triki, M., Abdehedi, R., Abaza, W., Moussa, H., Abdeslam, A. & Ben Salah, R. (2019). Incorporation of probiotic strain in raw minced beef meat: Study of textural modification, lipid and protein oxidation and color parameters during refrigerated storage. Meat Science, 154, 29–36. https://doi.org/10.1016/j.meatsci.2019.04.005
Uztimür, M., Kizil, Ö. & Akbulut, H. H. (2024). Immunophenotyping of peripheral circulating lymphocytes and serum selenium levels in calves with neonatal diarrhea. Veterinary Immunology and Immunopathology, 269, e110728. https://doi.org/10.1016/j.vetimm.2024.110728
Villot, C., Chen, Y., Pedgerachny, K., Chaucheyras-Durand, F., Chevaux, E., Skidmore, A., Guan, L. L. & Steele, M. A. (2020). Early supplementation of Saccharomyces cerevisiae boulardii CNCM I-1079 in newborn dairy calves increases IgA production in the intestine at 1 week of age. Journal of Dairy Science, 103(9), 8615–8628. https://www.sciencedirect.com/science/article/pii/S0022030220305397
Wang, J., Tong, T., Yu, Ch. & Wu, Q. (2025). The research progress on the impact of pig gut microbiota on health and production performance. Frontiers in Veterinary Science, 12, e1564519. https://doi.org/10.3389/fvets.2025.1564519
Wu, Y., Li, X., Tan, F., Zhou, X., Mu, J. & Zhao, X. (2021). Lactobacillus fermentum CQPC07 attenuates obesity, inflammation and dyslipidemia by modulating the antioxidant capacity and lipid metabolism in high-fat diet induced obese mice. Journal of Inflammation, 18, e5. https://doi.org/10.1186/s12950-021-00272-w
Xu, H., Huang, W., Hou, Q., Kwok, L.-Y., Sun, Z., Ma, H., Zhao, F., Lee, Y.-K. & Zhang, H. (2017). The effects of probiotics administration on the milk production, milk components and fecal bacteria microbiota of dairy cows. Science Bulletin, 62(11), 767–774. https://doi.org/10.1016/j.scib.2017.04.019
Yang, J., Li, Y., Sun, M., Zhang, Y., Guo, S., Zhou, D., Lin, P., Wang, A. & Jin, Y. (2025). Associations of rumen and rectum bacteria with the sustained productive performance of dairy cows. . Frontiers in Microbiology, 16, e1565034. https://doi.org/10.3389/fmicb.2025.1565034
Zhao, C., Hu, X., Zhang, N. & Fu, Y. (2025). Emerging role of ruminal microbiota in the development of perinatal bovine diseases. Animals and Zoonoses, 1(1), 86–98. https://doi.org/10.1016/j.azn.2024.06.002
Descargas
Publicado
Cómo citar
Número
Sección
Licencia
Derechos de autor 2026 Carmen Dolores Zambrano Cornejo , Gustavo Adolfo Campozano Marcillo

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.

_(Custom).jpg)













